- The total dose received
- The treated area
- The depth of penetration of the radiation
- Individual sensitivity (age, nutritional status, comorbidities, concomitant treatments).
Radiation causes immediate damage to the cells of the germinal layer of the epidermis. It causes a release of free radicals causing oxidative stress, small breaks in the DNA chain and inflammation.
This damage to the germinal cells of the epidermis reduces the regeneration capacity of the skin, making it thinner, redder and more fragile.
THE VARIABLES ASSOCIATED WITH THE DEVELOPMENT OF RADIODERMITIS ARE:
Skin photosensitivity phenotype.
Treatment field. Not all areas of the body are equally sensitive.
Dose. The toxic effect of radiotherapy is cumulative depending on the total dose received.
- Associated treatments such as chemotherapy.
- Biological treatments.
- The presence of some diseases such as psoriasis, atopic dermatitis, liver disease, kidney disease, diabetes.
Hand-foot syndrome occurs when drugs used to treat cancer affect the growth of skin cells or capillaries in the hands and feet. May progress to ulceration, infection, and loss of function.
Dryness of the skin, conjunctiva and other membranes. It is very common after the rash. It is treated with hygiene with specific soaps and hydration.